is reconstitution solution the same as bacteriostatic water?

1996-2023 RxList, Inc. An Internet Brands company. This should hopefully shed some light on an easily confusing topic on which water to use. Bacteriostatic water is in many cases the best solvent or dilutant for injections of medications and other therapeutic substances, such as peptides and hormones. Do NOT reuse the same saline syringe to flush VADs before and after medication administration. If the peptide still doesnt get dissolved, perform trial and error and use various other solvents. Reconstitution Solution 4-Pack (30mL) Bactostatic Labs. Scan this QR code to download the app now. Do not store reconstituted solutions of drugs for injection unless otherwise directed by the manufacturer of the solute. PHARM TEST #2: Reconstitution Flashcards | Quizlet It is essential to avoid repeated freeze-thaw cycles and exposure to light and high temperatures. You use Bac.Water to backload the pin. Some of the older lyophilizers cannot tolerate steam under pressure and sterilization is marginal at best. Do not use unless the solution is clear and seal intact. So, if you are someone who has seen the vials of both types of water, I am sure you can now understand why a bacteriostatic water vial contains considerable volume while a sterile water vial contains just a few milliliters. There may be cases in which sterile water is more appropriate, as outlined above. While most of the peptides will be soluble in bacteriostatic water and sterile water, some really wont, and this will be depending on the polarity of the peptides. I have this same question. Now, before you start flexing your peptide muscles, you need to learn the proper way to reconstitute them. Because there is 1ml of bacteriostatic water, this means that we need to mix 5000mcg with 1ml of bacteriostatic water. To do the reconstitution you will need: Vial . Bacteriostatic water has a 0.9% benzyl alcohol content and an average pH level of 5.7, while sterile water is free of additives with a pH level of 5.0-7.0. Typically available as lyophilized powders to maintain purity and integrity, peptides require reconstitution before injection [12]. If you are a peptide researcher or laboratory professional, you can safely enjoy the benefits of bacteriostatic water with proper use. Using either in the proper conditions can provide extraordinary results. The pH is 5.7 (4.5 to 7.0). Buckle LLC, including its officers, directors and employees shall not be held liable for any indirect, consequential or special liability arising out of or in any way related to your use of this Website. This parenteral preparation is indicated only for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be administered. When reconstituted with Bacteriostatic Water for Injection, USP, the resulting solution must be used within 7 days. You are specifically restricted from all of the following. Statements regarding products presented on Peptides.org are the opinions of the individuals making them and are not necessarily the same as those of Peptides.org. Long-term storage: For long-term storage, it is recommended to aliquot the reconstituted peptide into small volumes and freeze them at -20C or -80C. Another key difference is availability. 1) Determine the quantity of peptide, in micrograms (mcg), in your vial. Bacteriostatic water works well as a peptide solvent, reconstituting the compounds without compromising their effectiveness. Example would be 5g of CJC-1295 and 5g of ipamorelin. Note that you cant administer bacteriostatic water into your body without diluting it with any medication as the benzyl alcohol could trigger adverse cellular reactions into your body. PDF Zomacton Description There is literally no other option. The choice is purely up to the user which solution to use. 5.0 out of 5 stars Good product. The benzyl alcohol in the water makes bacteriostatic water ideal for diluting any drug that will be administered by intramuscular, intravenous, or subcutaneous injection. All rights reserved. and ADVERSE REACTIONS. tion ()r-kn (t)-st-t (y)-shn. Okay, so this is some maths stuff that I need to explain to you before it really gets on your nerves. False Product Partnering is our major thrust area and to facilitate this process. Injection of HGH is considered safe when prescribed by a doctor. We comply with the HONcode standard for trustworthy health information. No more confusion or frustration, just pure peptide power! This parenteral preparation is unlikely to You are granted limited license only for purposes of viewing the material contained on this Website. Leucovorin Calcium - GlobalRPH Although rarely, but they can occur, those side effects are more related to the drug that is dissolved in the bacteriostatic water. Some drugs for injection may be incompatible in a given vehicle, or when combined in the same vehicle or in a vehicle containing benzyl alcohol. For example, the recommended dosage of BPC-157 is 1mcg to 10mcg per kg of body weight which accounts for 200mcg to 1000mcg per injection. I'm diluting my AA (vinegar) to get to 0.6% AA. Side Effects of Bacteriostatic Water (Bacteriostatic Water for - RxList Two sterile solutions that are commonly used are bacteriostatic water and sterile water. 3, pp. Bacteriostatic Water for Injection, USP is a sterile, nonpyrogenic preparation of water for injection containing 0.9% (9 mg/mL) or 1.1% (11 mg/mL) benzyl alcohol added as a bacteriostatic preservative. Sorry Red, I was ambiguous with my 1st post. Cloudflare Ray ID: 7c0dd6108cb23fde This discussion will address some of the problems associated with the manufacture and control of a lyophilized dosage form. Do NOT use sterile water for injection for flushing VADs. You can email the site owner to let them know you were blocked. Bacteriostatic 0.9% Sodium Chloride Injection, USP is a sterile, nonpyrogenic, isotonic solution of sodium chloride in water for injection. Privacy Policy. More posts from r/Peptides 46K subscribers Hour_Love5645 6 days ago NSFW The volume of the preparation to be used for diluting or dissolving any drug for injection is dependent on the vehicle concentration, dose and route of administration as recommended by the manufacturer. Both meet US Pharmacopeia (USP) standards. Well, people have been mixing peptides in the same syringe and then administering them. Water balance is maintained by various regulatory mechanisms. Do not store reconstituted solutions of drugs for injection unless otherwise directed by the manufacturer of the solute. Researchers also use organic solvent such as Acetic acid and DMSO to dissolve hydrophobic peptides and polar uncharged amino acids. Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation. Unlike a powder or liquid fill, a low fill would not be readily apparent after lyophilization. IMPORTANT - Use only Bacteriostatic Water for Injection with Benzyl Alcohol . Lysis is the breaking down of a cell or membrane. This guide has you covered. The benzyl alcohol in it would cause red blood cell lysis. These are not all the possible side effects of Bacteriostatic Water. Failure to do so risks the development of hemolysis, damaging the red blood cells [9, 10]. Note that you should absolutely not stir or shake the vial as it is going to damage the peptide and it will no longer be effective. Mrose . Provisions for sterilizing the inert gas or air supply lines. As with any ethylene oxide treatment, humidification is necessary. The absence of a bacteriostat in sterile water only allows for a one time use. May contain hydrochloric acid for pH adjustment. A major difference between the two is the patient population. A verification code will be sent to you. In summary, the best way to store reconstituted peptides depends on the duration of storage and the desired shelf life. Correctly reconstituting peptides is essential in their effectiveness. No information provided. Bacteriostatic water (BW) has a pH of about 5.7. As defined in Section 10.01. However, this method requires special equipment and expertise. The re-use of sterile water for injections is strictly prohibited. Because most peptides are sold in powder form, one needs to dissolve/dilute them before really using them. First, lets break down the basics of sterile water. PT-141 can be reconstituted in bacteriostatic water (BAC) or sterile water. Once vials are partially stoppered, they are transported to the lyophilizer. Bacteriostatic Water Vs. Sterile Water Bacteriostatic water and sterile water are essentially used for the same function which is to dissolve the drugs/medications for injecting purposes. The volume of the preparation to be used for diluting or dissolving any drug for injection is dependent on the vehicle concentration, dose and route of administration as recommended by the manufacturer. Create your account and enjoy a new shopping experience. Sterile water is formulated for irrigation, such as rinsing wounds, unlike bacteriostatic water. Some measures are necessary - do not inject the water straight into the powder with force, usually, do not drop or shake a reconstituted vial. If symptoms appear, injections should be discontinued pending medical consultation [9]. Differences Between Bacteriostatic Water vs. Sterile Water It is also not known whether Bacteriostatic Water (bacteriostatic water (bacteriostatic water for injection) for injection) for Injection containing additives can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Additionally, this stability testing should include least concentrated as well as the most concentrated reconstituted solutions. Freeze-drying: Freeze-drying, also known as lyophilization, is a method that removes water from the peptide solution and allows the peptide to be stored in a stable, dry form at room temperature for an extended period. Both sterile solutions are formulated for medical use. Good practice and a good quality assurance program would include the frequent monitoring of the volume of fill such as every 15 minutes. HCG solutions are to be refrigerated to prevent degradation [19]. In order to reconstitute 10 equal dosages, we need to mix 1ml of bacteriostatic water in all the 10 injections, which means 0.1ml of water per dosage. 1. If I have a 2mg bottle how much water total do I put into the vial? Bacteriostatic water is a sterile form of water that has been brought to a pH between 4.5 to 7.0. Gently remove the needle from the vial. Use only as a diluent or solvent. Plus, it is a great dilutant for a range of drugs and therapeutic substances, facilitating aqueous delivery without compromising potency or effectiveness. The following preparation is designed solely for parenteral use only after addition of drugs that require dilution or must be dissolved in an aqueous vehicle prior to injection. Benzyl alcohol, a preservative in Bacteriostatic Water for Injection, USP has been associated with toxicity in neonates. To make it easy for you to get the best materials, the Peptides.org team has perused the web and selected the single best online source for your injection material requirements: This trusted vendor has an impressive selection of full research kits for your convenience. If available, sonication may be performed in order to speed up the process. The concern with any microbiological level is the possible increase in endotoxins that may develop. It also is prepared with a bacteriostat, a compound used to prevent any bacterial growth. Bacteriostatic Water (bacteriostatic water (bacteriostatic water for injection) for injection) for Injection, USP containing additives should be given to a pregnant woman only if clearly needed. Wir verstehen die Bedeutung der Kunden auf dem richtigen Weg zum Erfolg bringen, und wir sind bereit, mit ihnen der Planung in allen Bereichen zu arbeiten. The action you just performed triggered the security solution. It depends on the compound, there is no universal conversion, About: Muscle and Brawn is a coaching company specializing in bodybuilding, hormones, peptides, anabolics, and other biohacking. Bacteriostatic Water is available generically and has the same name. For more information, please see our Curious about Bacteriostatic Water for injections? Bacteriostatic Water (bacteriostatic water for injection) is a highly purified, sterilized water containing 0.9% benzyl alcohol that is used to dilute or dissolve medications to the appropriate consistency for injection. Avoid repeated freeze-thaw cycles: It is essential to avoid repeated freeze-thaw cycles, as they can cause damage to the peptide and decrease its stability and activity. By using this Website, you agreed to accept all terms and conditions written in here. Data are unavailable on the toxicity of other preservatives in this age group.

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